Office: HCCLB 1.8
Lab: HCCLB 1.7
Website: Sarkar Lab
1987 BS Presidency College, University of Calcutta, Calcutta, India
1990 MS University College of Science and Technology, University of Calcutta, Calcutta, India
1995 PhD Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
Member, Immunology Graduate Program
Member, Molecular Virology And Microbiology Graduate Program
Assistant Professor, Dept. of Microbiology and Molecular Genetics University of Pittsburgh
Member, Cancer Virology Program University of Pittsburgh Cancer Institute
Title: Novel Modifiers of Toll-like and RIG-like Receptor Signaling.
03/15/2009 - 02/28/2014
Title: Novel Small-Molecule inhibitors of TLR3 - IRF-3 signaling pathway
Agency: American Heart Association
01/01/2007 - 12/31/2010
Innate immunity of an organism is the inborn protection against invading pathogens. Because it is inborn, and entrusted with the protection of host from a vast array of previously unknown invaders, the innate immune system generates a generalized alert response upon pathogen detection. This alert is chemically mediated by a class of molecules called Cytokines. A critical task for this host protection system is to distinguish foreign or non-self, from self, and initiate their destruction or containment. The sensors or the receptors of the innate immune system accomplish this by recognizing specific molecular patterns, which are common to pathogens or pathogen associated molecules, but absent in the host. We focus on a particular subset of these sensors/receptors, which are involved in sensing virus infection.
We study four related aspects of innate immunity:
(A) The signaling process involved in cytokine production after virus infection.
(B) Develop modulators for these signaling pathways.
(C) How virus evade host innate immune response? and
(D) The contribution of innate immune response in cancer.
Zhu, J., Smith, K., Hsieh, P.N., Mburu, Y. K., Chattopadhyay, S., Sen, G.C. and Sarkar, S.N.(2010) A high throughput screening for TLR3-IRF3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors. J. Immunol. (in press).
Beura, LK, Sarkar, SN*, Kwon, BJ, Subramaniam, S, Jones, C, Pattnaik, AK, Osorio, FA* 2009. Porcine reproductive and respiratory syndrome virus non structural protein 1a modulates host innate immune response by antagonizing IRF3 activation J. Virol. 2009 Nov 18. (*Corresponding Authors).
Sen, GC and Sarkar, SN. 2007. "The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses" Curr Top Microbiol Immunol. 316: 233-250.
Sarkar SN, Elco CP, Peters KL, Chattopadhyay S, Sen GC. 2007. "Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation" J Biol Chem. 282:3423-7.
Sen, GC and Sarkar SN. 2005. "Hitching RIG to action" Nat Immunol. 6: 1074-1076.View Complete Publications Listing