Office: G.17a HCC
M.D. - University of Aarhus (1984)
Ph.D. - University of Aarhus (1992)
D.M.Sci. - University of Aarhus (1996)
Associate Professor, Department of Immunology, School of Medicine, University of Pittsburgh
Member, University of Pittsburgh Cancer Institute
Natural killer and T cell traffic in vivo
Tumor infiltration by immune effector cells
NK cell and dendritic cell interactions
Ex vivo production of highly cytotoxic NK cells
Adoptive transfer of NK cells and other anti-cancer effector cells
Use of tumor-seeking NK cells for the delivery of anti-cancer agents selectively to tumor sites
Dietary products and NK cell activity
Metastasis formation and resistance to immune cell infiltration
Research Assistant Professor
Title: Integrating NK and DC into Cancer Therapy
Type: Project (in P01 - PI: Michael T. Lotze)
Role: Project leader
Funding Period: 2005-2011
Title: Augmentation of NK cell-mediated anti-cancer activity by dietary BITC
Funding Period: 2009-2011
Title: Directing Tumor Specific T cells to Tumors
Type: P01 (PI: Pawel Kalinski)
Funding Period: 2009-2013
Title: Lanthanide Containing ZnS Nanoaparticles
Type: R21 (PI: David Waldeck)
Funding Period: 2009-2010
Our main goal is to develop an effective treatment of cancer based on immune cells. We study how immune effector cells, in particular natural killer (NK) cells, traffic in the body and how they are able to infiltrate and kill solid tumors. We are also exploring methods by which we can "arm" the tumor-seeking NK cells, so they can bring anti-cancer agents selectively to tumor sites. Since adoptively transferred, IL-2-activated NK cells (called A-NK cells) infiltrate some, but not all metastases, we are investigating the process of metastasis to determine why some metastases develop a phenotype which is fairly resistant to infiltration by A-NK cells.
Zamboni WC, Eiseman JL, Strychor S, Rice PM, Joseph E, Zamboni BA, Donnelly MK, Shurer J, Parise RA, Tonda ME, Yu NY, & Basse PH. Tumor disposition of pegylated liposomal CKD-602 and the reticuloendothelial system in preclinical tumor models. J Liposome Res. In press.
Yang Q, Larsen SK, Mi Z, Robbins PD, Basse PH. PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes. AAPS J 2008;10:614-21.
Goding S, Yang Q, Knudsen KB, Potter DM, Basse PH: Cytokine gene therapy using adenovirally transduced, tumor-seeking A-NK cells. Human Gene Therapy, 2007;18:701-711
Goding SR, Yang Q, Mi Z, Robbins PD, Basse PH. Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cells. Cancer Gene Therapy. Cancer Gene Ther 2007;14:441-450.
Yang Q, Goding S, Hagenaars M, Carlos T, Albertsson P, Kuppen P, Nannmark U, Hokland ME, Basse PH. Morphological appearance, content of extracellular matrix, and vascular density of lung metastases predicts permissiveness to infiltration by adoptively transferred natural killer and T cells. Cancer Immunol Immunother 2006;55(6):699-707.View Complete Publications Listing